Mate Maus

Sep 16, 2024 | nature.com | Ania Alay |Javier Vaquero |Mate Maus |Manuel Serrano |Maria Luz Martinez-Chantar

AbstractIron overload and cellular senescence have been implicated in liver fibrosis, but their possible mechanistic connection has not been explored. To address this, we have delved into the role of iron and senescence in an experimental model of chronic liver injury, analyzing whether an iron chelator would prevent liver fibrosis by decreasing hepatocyte senescence. The model of carbon tetrachloride (CCl4) in mice was used as an experimental model of liver fibrosis.