Javier Vaquero

Sep 16, 2024 | nature.com | Ania Alay |Javier Vaquero |Mate Maus |Manuel Serrano |Maria Luz Martinez-Chantar

AbstractIron overload and cellular senescence have been implicated in liver fibrosis, but their possible mechanistic connection has not been explored. To address this, we have delved into the role of iron and senescence in an experimental model of chronic liver injury, analyzing whether an iron chelator would prevent liver fibrosis by decreasing hepatocyte senescence. The model of carbon tetrachloride (CCl4) in mice was used as an experimental model of liver fibrosis.

Jun 14, 2024 | pathsocjournals.onlinelibrary.wiley.com | Ester Gonzalez-Sanchez |Digestive Diseases |ISCIII Madrid Spain |Javier Vaquero

Introduction Fibrosis is a highly conserved and coordinated, initially protective, response to tissue injury. The interaction among multiple pathways determines whether fibrosis is self-limiting and homeostatic or whether it is uncontrolled and excessive [1]. When a chronic injury takes place in the liver, mobilization of lymphocytes and other inflammatory cells occurs, thus setting the stage for persistence of an inflammatory response.

Jan 16, 2024 | gut.bmj.com | Reka Toth |Paul Brindley |Javier Vaquero |CSIC-Universidad de Salamanca

Enhancing the opportunities for cholangiocarcinoma precision therapy Statistics from Altmetric.com Request Permissions If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

Nov 5, 2023 | biorxiv.org | Ester Gonzalez-Sanchez |Javier Vaquero |Jan Grzelak |Daniel Caballero-Diaz

AbstractBackground & Aims: Liver fibrosis is the consequence of chronic liver injury in the presence of an inflammatory component. Although the main executors of this activation are known, the mechanisms that lead to the inflammatory process that mediates the production of profibrotic factors are not well characterized.

Oct 7, 2023 | onlinelibrary.wiley.com | Nassima Benzoubir |Javier Vaquero |Vanessa Bou Malham

bFGF basic fibroblast growth factor CAFs cancer-associated fibroblasts CCA cholangiocarcinoma CK19 cytokeratin 19 eCCA extrahepatic CCA, CSCs, Cancer stem cells ECM extracellular matrix EMT epithelial to mesenchymal transition EpCAM epithelial cell adhesion molecules GO-BP gene ontology biological process HCC hepatocellular carcinoma iCCA intrahepatic CCA MDCK Madin-Darby canine kidney pCCA Perihilar CCA PI3K phosphoinositide 3-kinase PIGF placental growth factor TGFβ transforming growth...