Matias Eliseo Melendez

Oct 21, 2023 | nature.com | Matias Eliseo Melendez

AbstractKnowledge on the molecular and clinical characteristics of head and neck squamous cell carcinoma (HNSCC) is vast. However, an effective therapy that increases the life expectancy of these patients, with a 5-year overall survival of 50%, is still unknown. Here we evaluated the combined effect of the pro-apoptotic protein rhTRAIL with the replication-competent wild-type HSV-1 virus in head and neck cancer cell lines.

Jul 31, 2023 | onlinelibrary.wiley.com | Bruna Pereira Sorroche |Matias Eliseo Melendez |Ana Carolina Laus |André Carvalho

DATA AVAILABILITY STATEMENT The data that support the findings of this study are available from the corresponding author upon reasonable request.

Jul 31, 2023 | pericles.pericles-prod.literatumonline.com | Bruna Pereira Sorroche |Ana Carolina Laus |André Carvalho |Matias Eliseo Melendez

ORIGINAL ARTICLE Cristiane Pereira Vargas Cousseau and Bruna Pereira Sorroche contributed equally to this study. Section Editor: James William Rocco Abstract Background Metastatic lymph node involvement influences therapy decisions and serves as a prognostic indicator in oral squamous cell carcinoma (OSCC). However, many early-stage patients with clinically negative lymph nodes exhibit no metastasis upon surgical staging.