Matilde E. LLeonart

Jun 20, 2023 | frontiersin.org | Nanyang Normal |Matilde E. LLeonart |Mani Larijani |Xiaoxia Liu

1 IntroductionThe human APOBEC3 (apolipoprotein B mRNA editing catalytic polypeptide-like 3, A3s) gene family consists of seven cytidine deaminases (A3A, A3B, A3C, A3D, A3F, A3G, and A3H), which are located on chromosome 22 (1). Members of the A3 family reportedly play a role in the innate immune response to viral infections and can also cause damage to cellular DNA, potentially contributing to the initiation and progression of cancer (2, 3).