Matthew C. Kiernan

Jan 6, 2025 | onlinelibrary.wiley.com | Emily O'Keefe |Matthew C. Kiernan |William Huynh

CASE DESCRIPTION A 53-year-old Greek woman presented with a 25-year history of slowly progressive spastic paraparesis. Symptom onset was asymmetrical at age 30, affecting the right lower limb before involving the left within months, leading to recurrent falls. She denied upper limb, bulbar or respiratory symptoms, reporting only mild bladder overactivity. Her medical history included well-controlled hypothyroidism, with no family history of neurological disorders.

Nov 7, 2023 | onlinelibrary.wiley.com | Matthew C. Kiernan |Glenda M Halliday |Dominic Rowe |Rachel Tan

No abstract is available for this article. 1, , , et al. Treatment with the copper compound CuATSM has no significant effect on motor neuronal pathology in patients with ALS. Neuropathol Appl Neurobiol. 2023; 49(4):e12919. doi:10.1111/nan.12919 2, , . CuII(atsm) significantly decreases microglial reactivity in patients with sporadic ALS. Neuropathol Appl Neurobiol. 2023; 49(5):e12938. doi:10.1111/nan.12938 3, , , , , . Review: microglia in motor neuron disease. Neuropathol Appl Neurobiol.