Matthew Hardcastle

Sep 19, 2024 | pnas.org | Matthew Hardcastle |Peter Grünwald |Wanqian Li |Siyuan He

Abstract The 2024 Albert Lasker Basic Medical Research Award was attributed to Zhijian (James) Chen for “the discovery of the cGAS enzyme that senses foreign and self DNA, solving the mystery of how DNA stimulates immune and inflammatory responses.” Bringing to bear an ingenious in vitro complementation system, an astute insight, and superlative biochemistry, Chen and colleagues identified cGAS (cGAMP synthase) as both the molecule that perceives cytosolic DNA in infected, stressed, or dying...

Oct 26, 2023 | lawgazette.co.uk | Matthew Hardcastle |Mimi Zou |Alicia Virtue |John Hyde

This year began with the launch of the Better Case Management (BCM) Revival Handbook. The Revival Handbook is built on the expectation of engagement between all parties. In short, the CPS and the defence ought to be in contact to progress cases as efficiently as possible. BCM has significant, and lasting, support from the senior presiding judge (Lord Justice Edis), but the response to a recent FOIA request by my firm Kingsley Napley suggests that historic difficulties are present once again.

Feb 21, 2023 | lexology.com | Matthew Hardcastle

Channel 4’s drama, Consent, aired this week about a rape scandal at a fictional prestigious public school involving 18 year old sixth former Archie and a bursary girl Natalie, has been described as essential viewing for teenagers and their parents, given it aim to ‘lift-the-lid’ on a culture of sexism and sexual violence in British schools today.

Feb 17, 2023 | lawgazette.co.uk | Matthew Hardcastle

Channel 4’s drama Consent, about a rape scandal at a fictional prestigious public school involving 18-year-old sixth former Archie and a bursary girl Natalie, has been described as essential viewing for teenagers and their parents, given its aim to ‘lift-the-lid’ on a culture of sexism and sexual violence in British schools today.