Matthew Howard

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Normative modelling of molecular-based functional circuits captures clinical heterogeneity transdiagnostically in psychiatric patients - Communications Biology

Jun 4, 2024 | nature.com | Timothy R. Lawn |Alessio Giacomel |Daniel Martins |Mattia Veronese |Matthew Howard |Federico Turkheimer

AbstractAdvanced methods such as REACT have allowed the integration of fMRI with the brain’s receptor landscape, providing novel insights transcending the multiscale organisation of the brain. Similarly, normative modelling has allowed translational neuroscience to move beyond group-average differences and characterise deviations from health at an individual level. Here, we bring these methods together for the first time.

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