Mattia Veronese

1 month ago | nature.com | Alessio Giacomel |Daniel Martins |Oliver Howes |Pierluigi Selvaggi |Federico Turkheimer |Ottavia Dipasquale | +1 more

AbstractMolecular neuroimaging techniques, like PET and SPECT, offer invaluable insights into the brain’s in-vivo biology and its dysfunction in neuropsychiatric patients. However, the transition of molecular neuroimaging into diagnostics and precision medicine has been limited to a few clinical applications, hindered by issues like practical feasibility, high costs, and high between-subject heterogeneity of neuroimaging measures.

Jul 22, 2024 | frontiersin.org | Mattia Veronese

Department of Information Engineering, University of Padova, Padova, Italy Paris Brain Institute, ICM, CNRS, Inserm, Sorbonne Université, Paris, France Athinoula A.

Jun 4, 2024 | nature.com | Timothy R. Lawn |Alessio Giacomel |Daniel Martins |Mattia Veronese |Matthew Howard |Federico Turkheimer

AbstractAdvanced methods such as REACT have allowed the integration of fMRI with the brain’s receptor landscape, providing novel insights transcending the multiscale organisation of the brain. Similarly, normative modelling has allowed translational neuroscience to move beyond group-average differences and characterise deviations from health at an individual level. Here, we bring these methods together for the first time.

Apr 30, 2024 | nature.com | Leonardo Sportelli |Daniel Eisenberg |Enrico D’Ambrosio |Michael Gregory |Thomas Hyde |Joel E. Kleinman | +6 more

AbstractThe polygenic architecture of schizophrenia implicates several molecular pathways involved in synaptic function. However, it is unclear how polygenic risk funnels through these pathways to translate into syndromic illness. Using tensor decomposition, we analyze gene co-expression in the caudate nucleus, hippocampus, and dorsolateral prefrontal cortex of post-mortem brain samples from 358 individuals.

Oct 23, 2023 | biorxiv.org | Timothy R. Lawn |Alessio Giacomel |Daniel Martins |Mattia Veronese

AbstractClinical neuroscience principally aims to delineate the neurobiology underpinning the symptoms of various disorders, with the ultimate goal of developing mechanistically informed treatments for these conditions. This has been hindered by the complex hierarchical organisation of the brain and extreme heterogeneity of neuropsychiatric disorders.