Matthew Lacorcia

1 month ago | science.org | John K. Mich |Itay Raphael |Raphaël Porret |Matthew Lacorcia |Pushpak Bhattacharjee |Abby Foster | +6 more

Editor’s summaryβ cell antigen–specific CD4+ T cell responses promote autoimmune destruction of insulin-producing pancreatic β cells. The ability to easily quantify the extent of such responses could potentially benefit the management of patients with or at risk of type 1 diabetes. Lacorcia et al. show that autoreactive CD4+ T cell responses to C-peptide can be accurately measured by detecting secreted IL-2.