Matthew Rendina

Nov 8, 2024 | biorxiv.org | Matthew Rendina |Peter J. Turnbaugh |Patrick Bradley

AbstractXenobiotics, including pharmaceutical drugs, can be metabolized by both host and microbiota, in some cases by homologous enzymes. We conducted a systematic search for all human proteins with gut microbial homologs. Because gene fusion and fission can obscure homology detection, we built a pipeline to identify not only full-length homologs, but also cases where microbial homologs were split across multiple adjacent genes in the same neighborhood or operon (split homologs).