Peter J. Turnbaugh

Nov 8, 2024 | biorxiv.org | Matthew Rendina |Peter J. Turnbaugh |Patrick Bradley

AbstractXenobiotics, including pharmaceutical drugs, can be metabolized by both host and microbiota, in some cases by homologous enzymes. We conducted a systematic search for all human proteins with gut microbial homologs. Because gene fusion and fission can obscure homology detection, we built a pipeline to identify not only full-length homologs, but also cases where microbial homologs were split across multiple adjacent genes in the same neighborhood or operon (split homologs).

Nov 4, 2024 | cell.com | Peter J. Turnbaugh |Chan Zuckerberg Biohub

Keywordsautoimmune diseasegut microbiomeketogenic dietketogenesisimmune activationneuroinflammationmultiple sclerosislactobacillustrytophan metabolismnutritionResearch topic(s)CP: MicrobiologyCP: ImmunologyIntroductionDiet has broad impacts on autoimmune disease, including multiple sclerosis (MS), inflammatory bowel disease, and rheumatoid arthritis,11. Sanchez, J.M.S. ∙ DePaula-Silva, A.B. ∙ Libbey, J.E. ... Role of diet in regulating the gut microbiota and multiple sclerosisClin. Immunol.

Jul 25, 2024 | cell.com | Byrne N.J |Rachel Carmody |Krista A. Varady |Peter J. Turnbaugh

SummaryThe past 50 years of interdisciplinary research in humans and model organisms has delivered unprecedented insights into the mechanisms through which diet affects energy balance. However, translating these results to prevent and treat obesity and its associated diseases remains challenging.

Jul 2, 2024 | nature.com | Cecilia Noecker |Peter J. Turnbaugh

AbstractThe human gut microbiome vastly extends the set of metabolic reactions catalysed by our own cells, with far-reaching consequences for host health and disease. However, our knowledge of gut microbial metabolism relies on a handful of model organisms, limiting our ability to interpret and predict the metabolism of complex microbial communities.

Jun 12, 2023 | elifesciences.org | Annamarie E Bustion |Renuka R. Nayak |Ayushi Agrawal |Peter J. Turnbaugh

Accepted manuscript, PDF only. Full online edition to follow. Author Accepted Manuscript PDF only version. The full online version will follow soon. Accepted Manuscript publishedJune 12, 2023 (This version) AcceptedJune 11, 2023 ReceivedAugust 3, 2022 Share this article Cite this article SIMMER employs similarity algorithms to accurately identify human gut microbiome species and enzymes capable of known chemical transformations eLife 12:e82401.