Matthias Zytnicki

Dec 11, 2024 | biorxiv.org | Claire Lemaitre |Matthias Zytnicki |Thomas Faraut |Siegfried Dubois

AbstractPangenome variation graphs are an increasingly used tool to perform genome analysis, aiming to replace a linear reference in a wide variety of genomic analyses. The construction of a variation graph from a collection of chromosome-size genome sequences is a difficult task that is generally addressed using a number of heuristics. The question that arises is to what extent the construction method influences the resulting graph, and the characterization of variability.

Oct 8, 2024 | biorxiv.org | Matthias Zytnicki

AbstractMotivation: With more and more telomere-to-telomere genomes assembled, pangenomes make it possible to capture the genomic diversity of a species. Because they introduce less biases, pangenomes, represented as graphs, tend to supplant the usual linear representation of a reference genome, augmented with variations. However, this major change requires new tools adapted to this data structure.

Apr 28, 2024 | biorxiv.org | Matthias Zytnicki

AbstractMotivation: With more and more telomere-to-telomere genomes assembled, pangenomes make it possible to capture the genomic diversity of a species. Because they introduce less biases, pangenomes, represented as graphs, tend to supplant the usual linear representation of a reference genome, augmented with variations. However, this major change requires new tools adapted to this data structure.