Siegfried Dubois

Dec 11, 2024 | biorxiv.org | Claire Lemaitre |Matthias Zytnicki |Thomas Faraut |Siegfried Dubois

AbstractPangenome variation graphs are an increasingly used tool to perform genome analysis, aiming to replace a linear reference in a wide variety of genomic analyses. The construction of a variation graph from a collection of chromosome-size genome sequences is a difficult task that is generally addressed using a number of heuristics. The question that arises is to what extent the construction method influences the resulting graph, and the characterization of variability.