Maxime Caron

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Mouse embryonic stem cells require sustained DNMT1-mediated DNA methylation maintenance for epigenomic, genomic and functional integrity

May 10, 2024 | biorxiv.org | Elizabeth Elder |Anthony Lemieux |Lisa-Marie Legault |Maxime Caron

AbstractOur research is motivated by the pivotal role of DNMT1 in maintaining DNA methylation, genomic stability, transposable element silencing, and imprinting alongside the extensive utilization of embryonic stem cells (ESCs) for modeling development and disease. Previously, we showed that DNA hypomethylation persisted throughout Dnmt1 inactivation and rescue in mouse ESCs (mESC), demonstrating their need for sustained DNMT1 activity.

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