Anthony Lemieux

May 10, 2024 | biorxiv.org | Elizabeth Elder |Anthony Lemieux |Lisa-Marie Legault |Maxime Caron

AbstractOur research is motivated by the pivotal role of DNMT1 in maintaining DNA methylation, genomic stability, transposable element silencing, and imprinting alongside the extensive utilization of embryonic stem cells (ESCs) for modeling development and disease. Previously, we showed that DNA hypomethylation persisted throughout Dnmt1 inactivation and rescue in mouse ESCs (mESC), demonstrating their need for sustained DNMT1 activity.

Sep 24, 2023 | biorxiv.org | Lisa-Marie Legault |Mélanie Breton-Larrivée |Alexandra Langford-Avelar |Anthony Lemieux

AbstractBackground: The placenta is vital for fetal development and its contributions to various developmental issues, such as pregnancy complications, fetal growth restriction, and maternal exposure, have been extensively studied in mice. Contrary to popular belief, the placenta forms mainly from fetal tissue; therefore, it has the same biological sex as the fetus it supports.