Meagher DJ

Sep 4, 2024 | pharmrev.aspetjournals.org | Walsh KA |O’Regan NA |Meagher DJ |Gerard Clarke

I. IntroductionThe principles of xenobiotic metabolism, which is defined as the metabolism of ingested exogenous molecules, emphasize the role of the liver as the predominant site of biotransformation after ingestion by the host. Within this convention, the liver is anatomically, morphologically, and physiologically specialized as a metabolic organ and unrivalled in metabolic capacity in comparison with extrahepatic host sites of chemical transformation (Michalopoulos, 2007).