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Nov 5, 2024 | 00399-1&sz=64)
cell.com | Gabriel S.S. Tofani |Sarah-Jane Leigh |Cassandra E. Gheorghe |Thomaz F.S. Bastiaanssen |Lars Wilmes |Paromita Sen | +2 more
Keywords circadian rhythms gut microbiota stress gut-brain axis glucocorticoid HPA axis Introduction The stress and circadian systems are intertwined, being an evolutionary conserved adaptation that allows the organism to respond to changes in the environment.1 Although the stress response is characterized as a rapid adaptive process to actual or perceived danger,2 the circadian rhythm is an endogenous process that anticipates predictable environmental cues.3 Although these two systems have...
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Oct 18, 2024 | 
tandfonline.com | Samantha L. Dawson |Gerard Clarke |Anne-Louise Ponsonby |Amy Loughman
ABSTRACTObjectives: In experimental models, the prenatal diet influences gut microbiota composition in mothers and offspring; however, it is unclear whether this occurs in humans. We investigated the effects of a gut-focused perinatal dietary intervention on maternal and infant gut microbiota composition four weeks after birth.
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Sep 4, 2024 | 
pharmrev.aspetjournals.org | Walsh KA |O’Regan NA |Meagher DJ |Gerard Clarke
I. IntroductionThe principles of xenobiotic metabolism, which is defined as the metabolism of ingested exogenous molecules, emphasize the role of the liver as the predominant site of biotransformation after ingestion by the host. Within this convention, the liver is anatomically, morphologically, and physiologically specialized as a metabolic organ and unrivalled in metabolic capacity in comparison with extrahepatic host sites of chemical transformation (Michalopoulos, 2007).
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Aug 22, 2024 | 
digitalcommons.library.tmc.edu | David M. Raizen |Janet M. Mullington |Christelle Anaclet |Gerard Clarke
To view the content in your browser, please download Adobe Reader or, alternately, you may Download the file to your hard drive. NOTE: The latest versions of Adobe Reader do not support viewing PDF files within Firefox on Mac OS and if you are using a modern (Intel) Mac, there is no official plugin for viewing PDF files within the browser window.
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Aug 21, 2024 | 
nature.com | Gerard Clarke
AbstractThe prevalence of brain disorders, including stress-related neuropsychiatric disorders and conditions with cognitive dysfunction, is rising. Poor dietary habits contribute substantially to this accelerating trend. Conversely, healthy dietary intake supports mood and cognitive performance.
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Jul 16, 2024 | 
nature.com | Gerard M Moloney |Gerard Clarke |Timothy G. Dinan
We thank Dr. Mullie & colleagues for expressing their interest in our study featuring a diet rich in prebiotic fibers and fermented foods, published in Molecular Psychiatry last year [1, 2]. This diet was designed to specifically target the gut microbiome with the intent to positively impact mental health in a healthy population.
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Apr 9, 2024 | 
enviromicro-journals.onlinelibrary.wiley.com | Sarah Nicolas |Gerard Clarke |John Cryan |Leonie Lang
INTRODUCTION With increasing longevity and declining fertility our global population is becoming disproportionality aged. Ageing is associated with an increased incidence of Alzheimer's disease (AD), which is now recognised as one of the most significant health challenges globally with important socio-economic dimensions (Alzheimer's disease facts and figures, 2022).
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Mar 20, 2024 | 
digitalrepository.unm.edu | Michaela M Milillo |Tessa Cappelle |Gerard Clarke |Craig S. Neumann
This is an original study that investigates correlates of traumatic brain injury (TBI; i.e., severity, total number of TBIs, age at first TBI) and psychopathic traits (i.e., antisocial or interpersonal qualities) in justice-involved adult males who were incarcerated at the time of their participation. Our results show higher levels of psychopathic traits in individuals with TBI versus those without, which suggests a greater need to target TBI in the treatment of justice-involved populations.
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Feb 28, 2024 | 
biorxiv.org | Rubén García-Cabrerizo |Maria Viola |Pauline Luczynski |Gerard Clarke
AbstractThe gut microbiota has been shown to be an important regulator of brain and behaviour. Germ-free rodents are a key model to study the microbiome-gut-brain axis to reveal the microbial underpinnings of diseases, including those related to psychiatric illnesses. The present study evaluated whether the absence of gut microbiota could alter the morphological development of the nucleus accumbens, a brain region located in the ventral striatum involved in stress, mood and addiction.
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Nov 22, 2023 | 
theliberal.ie | Gerard Clarke
The Dutch Freedom Party (PVV) is set to win around 35 of the 150 seats available making it the largest party in the Netherland’s parliament. The shock result means outspoken nationalist and Eurosceptic Geert Wilders will now be impossible to ignore in Dutch politics. Condemned as far right, racist and Islamphobic, Wilders was once even banned from the UK.
