Meenakshi Rajamohan

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Spatial transcriptomic analysis of primary and metastatic pancreatic cancers highlights tumor microenvironmental heterogeneity - Nature Genetics

Sep 18, 2024 | nature.com | Ateeq M. Khaliq |Kimia Mansouri |Asif Adil |Sikander Hayat |Mateusz Opyrchal |Meenakshi Rajamohan | +2 more

AbstractAlthough the spatial, cellular and molecular landscapes of resected pancreatic ductal adenocarcinoma (PDAC) are well documented, the characteristics of its metastatic ecology remain elusive. By applying spatially resolved transcriptomics to matched primary and metastatic PDAC samples, we discovered a conserved continuum of fibrotic, metabolic and immunosuppressive spatial ecotypes across anatomical regions.

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