Melanie Henkel

Oct 24, 2024 | onlinelibrary.wiley.com | Melanie Henkel |Virginie Marchand |Alexander Fillbrunn |Govindan Raghunathan

The most abundant epigenetic modification in the human genome is 5-methylcytosine (5 mC), accounting for 4 % of all cytosine (C) nucleobases.1 The postreplicative enzymatic addition of a methyl group to the 5-carbon atom of C is described as the process of DNA methylation2 and occurs mainly in a symmetrical pattern at 5′-cytosine-phosphate-guanine-3′ (CpG) dinucleotides.3 DNA methylation is involved in the regulation of gene expression4 and has a crucial impact on processes such as...