Virginie Marchand

2 weeks ago | nature.com | Stéphane Pelletier |Virginie Marchand |Delphine Naquin |Jessica Andreani |Yuri Motorin |Benoît Palancade

AbstractSmall nucleolar RNAs are non-coding transcripts that guide chemical modifications of RNA substrates and modulate gene expression at the epigenetic and post-transcriptional levels. However, the extent of their regulatory potential and the underlying molecular mechanisms remain poorly understood. Here, we identify a conserved, previously unannotated intronic C/D-box snoRNA, termed snR107, hosted in the fission yeast long non-coding RNA mamRNA and carrying two independent cellular functions.

Oct 31, 2024 | nature.com | Benjamin Pillet |Hussein Hamze |Virginie Marchand |Dieter Kressler |Olivier Gadal |Anthony K. Henras | +2 more

AbstractIntrinsically disordered regions (IDRs) are highly enriched in the nucleolar proteome but their physiological role in ribosome assembly remains poorly understood. Our study reveals the functional plasticity of the extremely abundant lysine-rich IDRs of small nucleolar ribonucleoprotein particles (snoRNPs) from protists to mammalian cells.

Oct 24, 2024 | onlinelibrary.wiley.com | Melanie Henkel |Virginie Marchand |Alexander Fillbrunn |Govindan Raghunathan

The most abundant epigenetic modification in the human genome is 5-methylcytosine (5 mC), accounting for 4 % of all cytosine (C) nucleobases.1 The postreplicative enzymatic addition of a methyl group to the 5-carbon atom of C is described as the process of DNA methylation2 and occurs mainly in a symmetrical pattern at 5′-cytosine-phosphate-guanine-3′ (CpG) dinucleotides.3 DNA methylation is involved in the regulation of gene expression4 and has a crucial impact on processes such as...

Aug 12, 2024 | biorxiv.org | Virginie Marchand |Yuri Motorin |Sandra Gillot |Agnes Baudin-Baillieu

AbstractCellular processes are governed by the regulation of gene expression, often at the level of translation control. The mechanisms of control have been shown to operate at various levels, but there is growing evidence to suggest that rRNA modification patterns play a key role in driving translational modulation of the ribosome. We investigated the intricate relationship between modification status and the decoding activity of the ribosome.

May 5, 2024 | mdpi.com | Alzbeta Chabronova |Andy Cremers |Virginie Marchand |Yuri Motorin

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