Melica Nourmoussavi Brodeur

Dec 4, 2024 | science.org | Mohammad Asghari |Melica Nourmoussavi Brodeur |Horacio Maldonado |Pradeep Singh

AbstractReceptor tyrosine kinases (RTKs) regulate many cellular functions and are important targets in pharmaceutical development, particularly in cancer treatment. EGFR and EphA2 are two key RTKs that are associated with oncogenic phenotypes. Several studies have reported functional interplay between these receptors, but the mechanism of interaction is still unresolved. Here, we use a time-resolved fluorescence spectroscopy called PIE-FCCS to resolve EGFR and EphA2 interactions in live cells.

Dec 4, 2024 | science.org | Mohammad Asghari |Melica Nourmoussavi Brodeur |Horacio Maldonado |Rui Zhang

AbstractConverting CO2 to methanol is crucial for addressing fuel scarcity and mitigating the greenhouse effect. Cu-based catalysts, with their diverse surface states, offer the potential to control reaction pathways and generate reactive H* species. However, a major challenge lies in oxidizing active Cu0 species by water generated during the catalytic process.

Dec 4, 2024 | science.org | Mohammad Asghari |Melica Nourmoussavi Brodeur |Horacio Maldonado |Xu Wang

AbstractArtificial ion channels with controllable mono/monovalent cation separation fulfill important roles in biomedicine, ion separation, and energy conversion. However, it remains a daunting challenge to develop an artificial ion channel similar to biological ion channels due to ion-ion competitive transport and lack of ion-gating ability of channels.

Dec 4, 2024 | science.org | Mohammad Asghari |Melica Nourmoussavi Brodeur |Horacio Maldonado |Haitao Qing

AbstractManta rays use wing-like pectoral fins for intriguing oscillatory swimming. It provides rich inspiration for designing potentially fast, efficient, and maneuverable soft swimming robots, which, however, have yet to be realized. It remains a grand challenge to combine fast speed, high efficiency, and high maneuverability in a single soft swimmer while using simple actuation and control.

Dec 4, 2024 | science.org | Mohammad Asghari |Melica Nourmoussavi Brodeur |Horacio Maldonado |Jie Qi

AbstractRefractory high-entropy alloys (RHEAs) are promising high-temperature structural materials. Their large compositional space poses great design challenges for phase control and high strength-ductility synergy.