Meng-ye Zhu

Jul 3, 2024 | onlinelibrary.wiley.com | Gang Xu |Fan Li |Xue-zhong Cao |Meng-ye Zhu

1 INTRODUCTION Patients with long-lasting or recurrent chronic pain are prone to adverse psychological consequences, particularly major depression and anxiety.1-3 The comorbidity of chronic pain and psychological disorders—a common clinical problem—poses significant challenges for current effective antidepressant and analgesic therapies, which are characterized by a lack of precise intervention targets and unavoidable severe side effects.4-6 Despite a rapidly growing body of literature...