Merve Aksöz

Aug 23, 2024 | science.org | Philipp Starkl |Merve Aksöz |Alessio Bevilacqua |Gustav Jönsson

Editor’s summaryInflammation caused by surgical tissue injury can evolve into chronic pain. Starkl et al. used a mouse model of surgical tissue injury to decipher a role for mast cell–derived metabolites in postoperative pain. Tetrahydrobiopterin (BH4) has been previously detected in injured nerves and correlates with pain intensity and is required for serotonin production by tryptophan hydroxylase (Tph1).

Aug 23, 2024 | science.org | Philipp Starkl |Merve Aksöz |Alessio Bevilacqua |Grigore-Aristide Gafencu

Editor’s summaryHematopoietic stem cells (HSCs) are required for blood cell production throughout life. Murine HSCs can be biased toward the megakaryocyte/platelet lineage, but whether platelet-biased human HSCs exist remains to be determined. Aksöz et al. combined molecular barcoding and single-cell RNA sequencing to track the fate of human HSCs (hHSCs) in vivo.

Aug 23, 2024 | science.org | Philipp Starkl |Merve Aksöz |Alessio Bevilacqua |Fabien Franco

Editor’s summaryAfter initial antigen encounter, some T cells persist and differentiate into long-lived memory cells. This process is accompanied by metabolic reprogramming that supports survival and memory functions, but the key factors driving memory T cell metabolic adaptation remain unclear. Using mouse models of viral infection and melanoma, Bevilacqua et al.