Alessio Bevilacqua

Aug 23, 2024 | science.org | Philipp Starkl |Merve Aksöz |Alessio Bevilacqua |Gustav Jönsson

Editor’s summaryInflammation caused by surgical tissue injury can evolve into chronic pain. Starkl et al. used a mouse model of surgical tissue injury to decipher a role for mast cell–derived metabolites in postoperative pain. Tetrahydrobiopterin (BH4) has been previously detected in injured nerves and correlates with pain intensity and is required for serotonin production by tryptophan hydroxylase (Tph1).

Aug 23, 2024 | science.org | Philipp Starkl |Merve Aksöz |Alessio Bevilacqua |Grigore-Aristide Gafencu

Editor’s summaryHematopoietic stem cells (HSCs) are required for blood cell production throughout life. Murine HSCs can be biased toward the megakaryocyte/platelet lineage, but whether platelet-biased human HSCs exist remains to be determined. Aksöz et al. combined molecular barcoding and single-cell RNA sequencing to track the fate of human HSCs (hHSCs) in vivo.

Aug 23, 2024 | science.org | Philipp Starkl |Merve Aksöz |Alessio Bevilacqua |Fabien Franco

Editor’s summaryAfter initial antigen encounter, some T cells persist and differentiate into long-lived memory cells. This process is accompanied by metabolic reprogramming that supports survival and memory functions, but the key factors driving memory T cell metabolic adaptation remain unclear. Using mouse models of viral infection and melanoma, Bevilacqua et al.

Sep 22, 2023 | science.org | Jie-Feng Yang |Fabien Franco |Feng Shan |Alessio Bevilacqua

Published In Science ImmunologyVolume 8 | Issue 87September 2023Article versionsSubmission historyReceived: 10 November 2022Accepted: 11 August 2023PermissionsRequest permissions for this article. AcknowledgmentsWe would like to thank all the blood donors in Taiwan, S.-H. Kuo at NYU for technical support, and S. Fuertes Marraco for scientific discussion and advice.

Sep 20, 2023 | nature.com | Noelia Maldonado-Pérez |Alessio Bevilacqua |Jhan-Jie Peng |Anouk Lepez |Kung-Chi Kao |Francisco Martin | +4 more

AbstractProtective immunity against pathogens or cancer is mediated by the activation and clonal expansion of antigen-specific naive T cells into effector T cells. To sustain their rapid proliferation and effector functions, naive T cells switch their quiescent metabolism to an anabolic metabolism through increased levels of aerobic glycolysis, but also through mitochondrial metabolism and oxidative phosphorylation, generating energy and signalling molecules1,2,3.