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1 month ago | 
clpmag.com | Chris Wolski |Metabolic Diseases
Summary:A study from Korea University highlights that premature menopause (before age 40) significantly increases the risk of Type 2 diabetes, emphasizing the need for early detection and lifestyle interventions. • Women who experience menopause before age 40 have a higher risk of developing Type 2 diabetes. • The absence of estrogen after early menopause may contribute to insulin resistance and glucose metabolism issues.
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Jan 13, 2025 | 
link.springer.com | Metabolic Diseases
AbstractThe molecular genetic diagnosis of congenital adrenal hyperplasia (CAH) is very challenging due to the high homology between the CYP21A2 gene and its pseudogene CYP21A1P.
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Dec 9, 2024 | 
diabetesjournals.org | Metabolic Diseases
Despite elucidation of the molecular genetic basis of several lipodystrophy syndromes, molecular defects in some ultra-rare subtypes of familial lipodystrophies remain unidentified. We analyzed whole exome sequencing (WES) data of four affected and two unaffected females from an undiagnosed autosomal dominant familial partial lipodystrophy (FPL) pedigree and identified only one novel heterozygous variant, p.Ala1603Tyr in NOTCH3 meeting the filtering criteria.
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Nov 25, 2024 | 
bmcmedicine.biomedcentral.com | Jumpertz von Schwartzenberg |van Hall |Metabolic Diseases |Heinrich Heine
Young non-obese men without known chronic disease were recruited to participate in a placebo-controlled, randomised, double-blind cross-over study to test the effects of carrageenan intake vs placebo, each over a period of 2 weeks, on insulin sensitivity and metabolism. The trial was performed at the Study Centre of the University Hospital Tübingen, Department of Internal Medicine IV (Endocrinology and Diabetology), Tübingen, Baden-Württemberg, Germany, between October 2015 and December 2016.
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Nov 7, 2024 | 00273-x?rss=yes&sz=64)
cell.com | Metabolic Diseases
KeywordsPCOSMASLDcardiovascular disease (CVD)fructosetriangulationMendelian randomizationGet full text accessLog in, subscribe or purchase for full access. References1. De Groot, P.C. ... PCOS, coronary heart disease, stroke and the influence of obesity: a systematic review and meta-analysisHum. Reprod. Update. 2011; 17:495-5002. Simons, P.I. ... Causal relationship between polycystic ovary syndrome and coronary artery disease: a Mendelian randomisation studyClin. Endocrinol. 2022; 96:599-6043. Jones, H.
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Nov 4, 2024 | 
cardiab.biomedcentral.com | Metabolic Diseases
ReferencesEmerging Risk Factors Collaboration, Sarwar N, Gao P, Seshasai SRK, Gobin R, Kaptoge S, et al. Diabetes mellitus, fasting blood glucose concentration, and risk of vascular disease: a collaborative meta-analysis of 102 prospective studies. Lancet Lond Engl. 2010;375:2215–22. https://doi.org/10.1016/S0140-6736(10)60484-9. Article CAS Google Scholar Jain V, Qamar A, Matsushita K, Vaduganathan M, Ashley KE, Khan MS, et al.
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Nov 1, 2024 | 
cardiab.biomedcentral.com | Metabolic Diseases
INSPIRE is a large-scale perioperative medical research database. The existing study has provided a comprehensive overview of this database [31]. It recruited a total of 274,919 patients who underwent various surgeries and received anesthesia management at Seoul National University Hospital from January 2011 to December 2020, resulting in a total of 376,839 surgical cases.
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Oct 22, 2024 | 
academic.oup.com | Metabolic Diseases
Accepted manuscripts are PDF versions of the author’s final manuscript, as accepted for publication by the journal but prior to copyediting or typesetting. They can be cited using the author(s), article title, journal title, year of online publication, and DOI. They will be replaced by the final typeset articles, which may therefore contain changes. The DOI will remain the same throughout. This content is only available as a PDF. This content is only available as a PDF. © The Author(s) 2024.
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Oct 17, 2024 | 
diabetesjournals.org | Maxime Lê |Metabolic Diseases |Endovascular Surgery |RWTH Aachen
Lesioned fascicles (LF) in the sciatic nerves of individuals with diabetic neuropathy (DN) correlate with clinical symptom severity. This study aimed to characterize the structural and molecular composition of these lesions to better understand DN pathogenesis. Sciatic nerves from amputees with and without type 2 diabetes (T2D) were examined using ex vivo magnetic resonance neurography, in vitro imaging, and proteomic analysis.
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Oct 6, 2024 | 
link.springer.com | Metabolic Diseases
AbstractWe previously showed that the rapid TSH (rTSH) screening is able to detect a high prevalence of thyroid diseases in patients presenting to the Emergency department (ED), with a 7% prevalence of undiagnosed thyroid dysfunctions. The purpose of the present study is to implement our diagnostic flow-chart for thyroid dysfunctions in the ED with a rapid point-of-care thyroid ultrasound (rPOCUS).
