Miao Xu

Dec 4, 2024 | onlinelibrary.wiley.com | Xiying Mao |Dandan Xia |Miao Xu |Yan Gao

1 Introduction Single-cell omics technologies, such as single-cell genome, epigenome, transcriptome, proteome, and metabolome, enable a deep depiction of the landscape of cellular molecular biological processes. They facilitate to describe the complete procedure of the “central dogma” and deconstructs the molecular interaction mechanism and targets from macromolecules (nucleic acids, proteins) to small molecules (metabolites), uncovering the nature of cellular heterogeneity.

Aug 11, 2023 | mdpi.com | Pengcheng Wu |Lili Zhang |Yan Zhao |Miao Xu

1. IntroductionPrediabetes, which is characterized by impaired glucose tolerance (IGT) and/or impaired fasting glucose (IFG) [1], represents a high-risk state for the development of diabetes, with an annual conversion rate of 5–10% [2], indicating that patients may progress to diabetes in the near future. Despite the absence of diabetes, it is also associated with a higher risk of cardiovascular disease, cancer, mental disorders, and mortality [3,4,5].