Michael C. Heinrich

2 weeks ago | nature.com | Andreas Hochhaus |Dong-Wook Kim |Jorge Cortés |Koji Sasaki |Michael J. Mauro |Timothy Hughes | +7 more

AbstractAsciminib is the first approved BCR::ABL1 inhibitor that Specifically Targets the ABL Myristoyl Pocket (STAMP). The present final analysis of the phase 1, open-label, nonrandomized trial (NCT02081378) assessed the long-term safety, tolerability, and antileukemic activity of asciminib in 115 patients with chronic myeloid leukemia in chronic phase without the BCR::ABL1T315I mutation who received asciminib 10–200 mg twice daily (BID) or 80–200 mg once daily (cutoff: March 14, 2023).

May 16, 2024 | nature.com | Jorge Cortés |Koji Sasaki |Timothy Hughes |Michael J. Mauro |Andreas Hochhaus |Michael C. Heinrich | +5 more

AbstractAsciminib targets the BCR::ABL1 myristoyl pocket, maintaining activity against BCR::ABL1T315I, which is resistant to most approved adenosine triphosphate–competitive tyrosine kinase inhibitors. We report updated phase I results (NCT02081378) assessing safety/tolerability and antileukemic activity of asciminib monotherapy 200 mg twice daily in 48 heavily pretreated patients with T315I-mutated chronic-phase chronic myeloid leukemia (CML-CP; data cutoff: January 6, 2021).

Mar 19, 2024 | dialnet.unirioja.es | Michael C. Heinrich

españolLa publicación del proyecto Marx-Engels Gesamtausgabe, las obras completas de Marx y Engels, abrirá a los estudiosos un Marx que ha sido desconocido y permitirá nuevas lecturas de su obra. Lo anterior no solo significará un redescubrimiento de Marx, sino al mismo tiempo una puesta en perspectiva de la lectura de los textos clásicos que ya conocemos. El artículo abordará algunos ejemplos de lo que esto puede significar.

Mar 13, 2024 | divisare.com | Michael C. Heinrich

Help us swim against the tide. Join us in taking a stand against the short attention architecture media. Divisare is the result of an effort of selection and classification of contemporary architecture conducted for over twenty years. Patient work, done with care, image after image, project after project, to offer you the ideal tool with which to organize your knowledge of contemporary architecture. Instead of a quick, distracted web, we want a slow, attentive one.

Dec 23, 2023 | theglobalist.com | Michael C. Heinrich |Markus Heinrich

Beauty and aesthetics – old-fashioned terms, it appears. They seem like they are from a bygone era, long before a crudely standardizing global mass media and lifestyle industry, or like pastimes of the rich and privileged living in their neat, watered paradises beyond high fences and thick hedges to the street. But no. Beauty belongs to all of us. And it has something to do with dignity.