Michael Erb

Oct 15, 2024 | cell.com | Benjamin Cravatt |Michael Erb

Keywords FOXA1 covalent proteomics activity-based protein profiling cysteine chromatin pioneer transcription factor ATAC-seq ChIP-seq Introduction Lineage-specific transcription is controlled by enhancers harboring transcription factor (TF)-binding sites.1 Most TFs, however, cannot associate with condensed (e.g., nucleosome-bound) DNA and therefore rely on pioneer TFs to first bind to and open such heterochromatin sites in a locus-specific manner.2 Due to their first-order control of enhancer...