Michael G Atser

Oct 14, 2024 | biorxiv.org | Elyn M. Rowe |Haoning Cen |Michael G Atser |Chelsea D Wenyonu

AbstractPyruvate dehydrogenase kinase (PDK) 1 is one of four isozymes that inhibit the oxidative decarboxylation of pyruvate to acetyl-CoA via pyruvate dehydrogenase. PDK activity is elevated in fasting or starvation conditions to conserve carbohydrate reserves. PDK has also been shown to increase mitochondrial fatty acid utilization. In cardiomyocytes, metabolic flexibility is crucial for the fulfillment of high energy requirements.