Haoning Cen

Jan 7, 2025 | cell.com | Jessica D. Ewald |Yao Lu |Cara E. Ellis |Jessica Worton |Jelena Kolic |Shugo Sasaki | +25 more

ForumVolume 37, Issue 1p7-11 1Institute of Parasitology, McGill University, Montreal, QC, Canada 2Imaging Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA 3Alberta Diabetes Institute, University of Alberta, Edmonton, AB, Canada 4Department of Pharmacology, University of Alberta, Edmonton, AB, Canada 5Department of Surgery, University of Alberta, Edmonton, AB, Canada 6Department of Cellular and Physiological Sciences, Life Sciences Institute, University of British Columbia,...

Jan 7, 2025 | cell.com | Jessica D. Ewald |Yao Lu |Cara E. Ellis |Jessica Worton |Jelena Kolic |Shugo Sasaki | +25 more

ForumVolume 37, Issue 1p7-11 1Institute of Parasitology, McGill University, Montreal, QC, Canada 2Imaging Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA 3Alberta Diabetes Institute, University of Alberta, Edmonton, AB, Canada 4Department of Pharmacology, University of Alberta, Edmonton, AB, Canada 5Department of Surgery, University of Alberta, Edmonton, AB, Canada 6Department of Cellular and Physiological Sciences, Life Sciences Institute, University of British Columbia,...

Oct 14, 2024 | biorxiv.org | Elyn M. Rowe |Haoning Cen |Michael G Atser |Chelsea D Wenyonu

AbstractPyruvate dehydrogenase kinase (PDK) 1 is one of four isozymes that inhibit the oxidative decarboxylation of pyruvate to acetyl-CoA via pyruvate dehydrogenase. PDK activity is elevated in fasting or starvation conditions to conserve carbohydrate reserves. PDK has also been shown to increase mitochondrial fatty acid utilization. In cardiomyocytes, metabolic flexibility is crucial for the fulfillment of high energy requirements.

Jul 2, 2024 | cell.com | Jelena Kolic |Wenqing Sun |Haoning Cen |Jessica D. Ewald |Jason C. Rogalski |Shugo Sasaki | +14 more

Keywordshuman isletstype 2 diabetesstem cell-derived isletsinsulin secretionproteomicsmacronutrientsRNA-seqIntroductionInsulin is released by pancreatic islet beta cells in response to nutrient stimuli to maintain energy homeostasis. The major driver of insulin secretion is glucose. However, proteins and fats may also modulate insulin release, and the effects of non-carbohydrate nutrients on insulin secretion remain underexplored.

Jun 7, 2024 | biorxiv.org | Haoning Cen |Xiaoke Hu |Jamie Chu |Bhavya Sabbineni

AbstractPancreatic β cells exist in low and high insulin gene activity states that are dynamic on a scale of hours to days. Cells with higher Ins2 gene activity have a mature β cell transcriptomic profile but are more fragile. Information remains unknown on the spatial relationship between these β cell states, their proteomic signatures, and the signaling mechanisms underlying state transitions.