Michael Lawrence

Oct 15, 2024 | medium.com | Michael Lawrence |Mehmet Yildiz

I used to think writing was like eating vegetables as a kid — something you had to do, not something you’d choose to do. Give me a camera any day, I’d say. Words? They were just the boring stuff between pictures in a magazine. Then life threw me a curveball, and suddenly I found myself staring at a blank document, tasked with writing a blog post. I had no idea. That blinking cursor was about to change everything I knew about communication, creativity, and myself.

Oct 15, 2024 | medium.com | Michael Lawrence |Mehmet Yildiz

Marcus Aurelius’ Guide to Conquering AdversityMichael Lawrence·FollowPublished inILLUMINATION·4 min read·--A serene Roman bust of Marcus Aurelius generated by MidjourneyImagine facing a global crisis without the internet, without modern medicine, and with the weight of an entire empire on your shoulders. This was the reality for Roman Emperor Marcus Aurelius in 165 AD.

Mar 17, 2024 | nature.com | Ramin Sakhtemani |Michael Lawrence

AbstractThe APOBEC3 enzymes convert cytosines in single-stranded DNA to uracils to protect against viruses and retrotransposons but can contribute to mutations that diversify tumors. To understand the mechanism of mutagenesis, we map the uracils resulting from expression of APOBEC3B or its catalytic carboxy-terminal domain (CTD) in Escherichia coli.

Sep 30, 2023 | nature.com | Michael Lawrence

AbstractThe roles of R-loops and RNA modifications in homologous recombination (HR) and other DNA double-stranded break (DSB) repair pathways remain poorly understood. Here, we find that DNA damage-induced RNA methyl-5-cytosine (m5C) modification in R-loops plays a crucial role to regulate PARP1-mediated poly ADP-ribosylation (PARylation) and the choice of DSB repair pathways at sites of R-loops.

Sep 6, 2023 | medium.com | Michael Lawrence

Disclosure: I only recommend products I use and love myself, and all opinions expressed here are honest and my own. This post may contain affiliate links that cost you nothing extra but allow me to earn a small commission. Dealing with criticism is often akin to swallowing a bitter pill. It has the power to awaken our insecurities, stoke self-doubt, or even ignite a fiery sense of defensiveness within us. It's a challenge we all face at some point in our lives.