Ramin Sakhtemani

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Distinguishing preferences of human APOBEC3A and APOBEC3B for cytosines in hairpin loops, and reflection of these preferences in APOBEC-signature cancer genome mutations | Nature Communications

Mar 17, 2024 | nature.com | Ramin Sakhtemani |Michael Lawrence

AbstractThe APOBEC3 enzymes convert cytosines in single-stranded DNA to uracils to protect against viruses and retrotransposons but can contribute to mutations that diversify tumors. To understand the mechanism of mutagenesis, we map the uracils resulting from expression of APOBEC3B or its catalytic carboxy-terminal domain (CTD) in Escherichia coli.
Therapy-induced APOBEC3A drives evolution of persistent cancer cells - Nature

Jul 5, 2023 | nature.com | Hideko Isozaki |Ramin Sakhtemani |Sunwoo Oh |Susanna Monroe |Varuna Nangia |Amanda Riley | +10 more

Author notesThese authors contributed equally: Michael S. Lawrence, Aaron N. HataAuthors and AffiliationsMassachusetts General Hospital Cancer Center, Boston, MA, USAHideko Isozaki, Ramin Sakhtemani, Ammal Abbasi, Naveed Nikpour, Marcello Stanzione, Adam Langenbucher, Susanna Monroe, Wenjia Su, Heidie Frisco Cabanos, Faria M. Siddiqui, Nicole Phan, Daria Timonina, Samantha Bilton, Maria Gomez-Caraballo, Hannah L.

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