Michael R. Kosorok

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Gene signatures derived from transcriptomic-causal networks stratify colorectal cancer patients for effective targeted therapy - Communications Medicine

Jan 8, 2025 | nature.com | Akram Yazdani |Benjamin Vincent |Xueping Qu |Michael R. Kosorok |William F. Symmans |Scott Kopetz | +1 more

AbstractGene signatures derived from transcriptomic-causal networks offer potential for tailoring clinical care in cancer treatment by identifying predictive and prognostic biomarkers. This study aimed to uncover such signatures in metastatic colorectal cancer (CRC) patients to aid treatment decisions. We constructed transcriptomic-causal networks and integrated gene interconnectivity into overall survival (OS) analysis to control for confounding genes.

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