Michael Tighe

Feb 16, 2024 | nature.com | In-Jeong Kim |Michael Tighe |Kelsey L. Travis |Timothy C. Low-Beer |Kathleen G Lanzer |Derek T. Bernacki | +7 more

AbstractZika virus (ZIKV) infection during pregnancy poses significant threats to maternal and fetal health, leading to intrauterine fetal demise and severe developmental malformations that constitute congenital Zika syndrome (CZS). As such, the development of a safe and effective ZIKV vaccine is a critical public health priority. However, the safety and efficacy of such a vaccine during pregnancy remain uncertain. Historically, the conduct of clinical trials in pregnant women has been challenging.

Feb 14, 2024 | nature.com | In-Jeong Kim |Michael Tighe |Vincent Dussupt |Shelly J. Krebs |Kelsey L. Travis |Tres Cookenham | +7 more

AbstractZika virus (ZIKV) is a significant threat to pregnant women and their fetuses as it can cause severe birth defects and congenital neurodevelopmental disorders, referred to as congenital Zika syndrome (CZS). Thus, a safe and effective ZIKV vaccine for pregnant women to prevent in utero ZIKV infection is of utmost importance. Murine models of ZIKV infection are limited by the fact that immunocompetent mice are resistant to ZIKV infection.

Jun 7, 2023 | science.org | Michael Tighe