Michelle J Wen

Jan 18, 2024 | cell.com | Mai-Anh T Vu |Eleanor Brown |Michelle J Wen |Christian A Noggle |Eleanor Brown |Zicheng Zhang | +11 more

Highlights•A new customizable, targeted, and dense micro-fiber array approach for behaving mice•Measurements and manipulations of distributed neural dynamics over large 3D volumes•Modality-specific patterns of striatum-wide dopamine release in response to salient stimuli•Spatial mapping of a behavioral function via serially targeted striatum stimulationsSummaryNeural population dynamics relevant to behavior vary over multiple spatial and temporal scales across three-dimensional volumes.

Nov 17, 2023 | biorxiv.org | Mai-Anh T Vu |Eleanor Brown |Michelle J Wen |Christian A Noggle

AbstractNeural population dynamics relevant for behavior vary over multiple spatial and temporal scales across 3-dimensional volumes. Current optical approaches lack the spatial coverage and resolution necessary to measure and manipulate naturally occurring patterns of large-scale, distributed dynamics within and across deep brain regions such as the striatum.