Mai-Anh T Vu

Aug 14, 2024 | biorxiv.org | Eleanor Brown |Mai-Anh T Vu |Safa Bouabid |Yihan Zi

AbstractGoal-directed navigation requires animals to continuously evaluate their current direction and speed of travel relative to landmarks to discern whether they are approaching or deviating from their goal. Striatal dopamine and acetylcholine are powerful modulators of goal-directed behavior, but it is unclear whether and how neuromodulator dynamics at landmarks incorporate relative motion for effective behavioral guidance.

Jan 18, 2024 | cell.com | Mai-Anh T Vu |Eleanor Brown |Michelle J Wen |Christian A Noggle |Eleanor Brown |Zicheng Zhang | +11 more

Highlights•A new customizable, targeted, and dense micro-fiber array approach for behaving mice•Measurements and manipulations of distributed neural dynamics over large 3D volumes•Modality-specific patterns of striatum-wide dopamine release in response to salient stimuli•Spatial mapping of a behavioral function via serially targeted striatum stimulationsSummaryNeural population dynamics relevant to behavior vary over multiple spatial and temporal scales across three-dimensional volumes.

Nov 17, 2023 | biorxiv.org | Mai-Anh T Vu |Eleanor Brown |Michelle J Wen |Christian A Noggle

AbstractNeural population dynamics relevant for behavior vary over multiple spatial and temporal scales across 3-dimensional volumes. Current optical approaches lack the spatial coverage and resolution necessary to measure and manipulate naturally occurring patterns of large-scale, distributed dynamics within and across deep brain regions such as the striatum.