Miguel Quirós

Sep 12, 2024 | nature.com | Yichen Si |Yongha Hwang |Weiqiu Cheng |Chun-Seok Cho |Miguel Quirós |Jun Lee

AbstractSpatial transcriptomics (ST) technologies have advanced to enable transcriptome-wide gene expression analysis at submicron resolution over large areas. However, analysis of high-resolution ST is often challenged by complex tissue structure, where existing cell segmentation methods struggle due to the irregular cell sizes and shapes, and by the absence of segmentation-free methods scalable to whole-transcriptome analysis.