Miin S. Lin

Jun 19, 2024 | elifesciences.org | Miin S. Lin |Se-Young Jo |Jens Luebeck |Howard Chang

eLife assessment This study of extrachromosomal DNA (ecDNA) identifies genes that distinguish ecDNA+ and ecDNA- tumors. The findings in the manuscript are important and the genomic analyses convincing. However, some of the data remain observational and the inferences would therefore be more robust with experimental validation. This manuscript could well be of relevance to biologists interested in cancer biology and gene regulation.