Milica Moskovjlevic

Mar 1, 2024 | biorxiv.org | Filippo Dragoni |Nathan L. Board |Fengting Wu |Milica Moskovjlevic

AbstractDespite antiretroviral therapy (ART), HIV-1 persists in latently-infected CD4+ T cells, preventing cure. Antigens drive the proliferation of infected cells, precluding latent reservoir decay. However, the relationship between antigen recognition and HIV-1 gene expression is poorly understood since most studies of latency reversal use agents that induce non-specific global T cell activation.