Fengting Wu

3 weeks ago | biorxiv.org | Fengting Wu |Milica Moskovjlevic |Filippo Dragoni |Sahana Jayaraman

AbstractAntiretroviral therapy (ART) halts HIV-1 replication, reducing plasma virus levels to below the limit of detection, but it is not curative due to a reservoir of latently infected CD4+ T cells. In some people living with HIV-1 (PLWH), plasma HIV-1 RNA becomes persistently detectable despite optimal ART. This nonsuppressible viremia (NSV) is characterized by identical, non-evolving HIV-1 RNA variants expressed from infected CD4+ T cell clones.

Nov 28, 2024 | cell.com | Milica Moskovljevic |Filippo Dragoni |Nathan L. Board |Fengting Wu |Jun S. Lai |Hao Zhang | +10 more

Keywords HIV-1 persistence HIV-1 latent reservoir latency reversal antigenic stimulation dendritic cells CD4+ T cells cytomegalovirus Introduction Antiretroviral therapy (ART) effectively blocks viral replication, but HIV-1 persists in a small pool of latently infected resting CD4+ T cells harboring inducible, replication-competent proviruses.1,2,3 This reservoir was originally characterized with a quantitative viral outgrowth assay (QVOA) in which resting CD4+ T cells are stimulated with...

Mar 1, 2024 | biorxiv.org | Filippo Dragoni |Nathan L. Board |Fengting Wu |Milica Moskovjlevic

AbstractDespite antiretroviral therapy (ART), HIV-1 persists in latently-infected CD4+ T cells, preventing cure. Antigens drive the proliferation of infected cells, precluding latent reservoir decay. However, the relationship between antigen recognition and HIV-1 gene expression is poorly understood since most studies of latency reversal use agents that induce non-specific global T cell activation.

Jan 25, 2024 | rupress.org | Joshua T. Kufera |Fengting Wu |Ciara Armstrong |Anushka Singhal

Citation Joshua T. KuferaCiara ArmstrongFengting WuAnushka SinghalHao ZhangJun LaiHannah N. WilkinsFrancesco R. SimonettiJanet D. SilicianoRobert F. Siliciano; CD4+ T cells with latent HIV-1 have reduced proliferative responses to T cell receptor stimulation. J Exp Med 4 March 2024; 221 (3): e20231511. doi: https://doi.org/10.1084/jem.20231511 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex

Nov 3, 2023 | biorxiv.org | Emily J. Fray |Fengting Wu |Carolin Zitzmann |Narmada Sambaturu

AbstractHIV can persist in a latent form as integrated DNA (provirus) in resting CD4+ T cells of infected individuals and as such is unaffected by antiretroviral therapy (ART). Despite being a major obstacle for eradication efforts, the genetic variation and timing of formation of this latent reservoir remains poorly understood. Previous studies on when virus is deposited in the latent reservoir have come to contradictory conclusions.