Fengting Wu

Nov 28, 2024 | cell.com | Milica Moskovljevic |Filippo Dragoni |Nathan L. Board |Fengting Wu |Jun S. Lai |Hao Zhang | +10 more

Keywords HIV-1 persistence HIV-1 latent reservoir latency reversal antigenic stimulation dendritic cells CD4+ T cells cytomegalovirus Introduction Antiretroviral therapy (ART) effectively blocks viral replication, but HIV-1 persists in a small pool of latently infected resting CD4+ T cells harboring inducible, replication-competent proviruses.1,2,3 This reservoir was originally characterized with a quantitative viral outgrowth assay (QVOA) in which resting CD4+ T cells are stimulated with...

Mar 1, 2024 | biorxiv.org | Filippo Dragoni |Nathan L. Board |Fengting Wu |Milica Moskovjlevic

AbstractDespite antiretroviral therapy (ART), HIV-1 persists in latently-infected CD4+ T cells, preventing cure. Antigens drive the proliferation of infected cells, precluding latent reservoir decay. However, the relationship between antigen recognition and HIV-1 gene expression is poorly understood since most studies of latency reversal use agents that induce non-specific global T cell activation.

Jan 25, 2024 | rupress.org | Joshua T. Kufera |Fengting Wu |Ciara Armstrong |Anushka Singhal

Citation Joshua T. KuferaCiara ArmstrongFengting WuAnushka SinghalHao ZhangJun LaiHannah N. WilkinsFrancesco R. SimonettiJanet D. SilicianoRobert F. Siliciano; CD4+ T cells with latent HIV-1 have reduced proliferative responses to T cell receptor stimulation. J Exp Med 4 March 2024; 221 (3): e20231511. doi: https://doi.org/10.1084/jem.20231511 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex

Nov 3, 2023 | biorxiv.org | Emily J. Fray |Fengting Wu |Carolin Zitzmann |Narmada Sambaturu

AbstractHIV can persist in a latent form as integrated DNA (provirus) in resting CD4+ T cells of infected individuals and as such is unaffected by antiretroviral therapy (ART). Despite being a major obstacle for eradication efforts, the genetic variation and timing of formation of this latent reservoir remains poorly understood. Previous studies on when virus is deposited in the latent reservoir have come to contradictory conclusions.

Feb 20, 2023 | cell.com | Emily J. Fray |Fengting Wu |Francesco Simonetti |Carolin Zitzmann

With this general formula, multiple models can be tested. If we fix b3=0, then the third phase of decay starting at time Ts is flat and remains at the value of y attained at time Ts. On the other hand, if we fix Ts at a large value (say Ts=10,000) then we never reach Ts and have the usual biphasic decay model. In this latter case, with A = 0, we can test for a single decay model, estimating only b2. Note that in the case of a single decay, b1 is not estimated.