Milos R. Popovic

Apr 11, 2024 | nature.com | Srdjan Sumarac |Jürgen Germann |Milos R. Popovic |Mojgan Hodaie |Alfonso Fasano |Andres M. Lozano | +2 more

AbstractDeep brain stimulation (DBS) of the subthalamic nucleus (STN) produces an electrophysiological signature called evoked resonant neural activity (ERNA); a high-frequency oscillation that has been linked to treatment efficacy. However, the single-neuron and synaptic bases of ERNA are unsubstantiated. This study proposes that ERNA is a subcortical neuronal circuit signature of DBS-mediated engagement of the basal ganglia indirect pathway network.