Srdjan Sumarac

Sep 11, 2024 | nature.com | Srdjan Sumarac |Mojgan Hodaie |Andres M. Lozano |Andrés Lozano |William Hutchison |Alfonso Fasano

AbstractParkinson’s disease (PD) has been associated with pathological neural activity within the basal ganglia. Herein, we analyzed resting-state single-neuron and local field potential (LFP) activities from people with PD who underwent awake deep brain stimulation surgery of the subthalamic nucleus (STN; n = 125) or globus pallidus internus (GPi; n = 44), and correlated rate-based and oscillatory features with UPDRSIII off-medication subscores.

Apr 11, 2024 | nature.com | Srdjan Sumarac |Jürgen Germann |Milos R. Popovic |Mojgan Hodaie |Alfonso Fasano |Andres M. Lozano | +2 more

AbstractDeep brain stimulation (DBS) of the subthalamic nucleus (STN) produces an electrophysiological signature called evoked resonant neural activity (ERNA); a high-frequency oscillation that has been linked to treatment efficacy. However, the single-neuron and synaptic bases of ERNA are unsubstantiated. This study proposes that ERNA is a subcortical neuronal circuit signature of DBS-mediated engagement of the basal ganglia indirect pathway network.