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Dec 5, 2024 | 
science.org | Milos S. Simic |Nishith Reddy |Nicholas Dulvy |Hasna Maachi |Yini Xiao |Wei Yu | +9 more
Research ArticleCELL ENGINEERINGNishith R. Reddy https://orcid.org/0000-0001-5912-6925, Hasna Maachi https://orcid.org/0009-0002-3044-2582, [...] , Yini Xiao https://orcid.org/0009-0007-5108-7301, Milos S. Simic https://orcid.org/0000-0002-1167-0857, [...] , Wei Yu https://orcid.org/0000-0002-3154-5084, Yurie Tonai https://orcid.org/0000-0001-9610-6667, Daniela A. Cabanillas https://orcid.org/0000-0002-1321-9656, Ella Serrano-Wu https://orcid.org/0009-0003-1666-1778, Philip T.
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Dec 5, 2024 | 
science.org | Milos S. Simic |Nishith Reddy |Nicholas Dulvy |Deodatta S. Gajbhiye
Editor’s summaryHatching of young animals from eggs is often timed to occur under favorable conditions. However, the brain mechanisms underlying the integration of sensory inputs used to determine hatching time and the neuronal circuits involved in hatching remain elusive. Gajbhiye et al. studied hatching in teleosts, showing that the thyrotropin-releasing hormone (Trh) is the neuroendocrine factor responsible for triggering hatching (see the Perspective by Argenton and Gothilf).
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Dec 5, 2024 | 
science.org | Milos S. Simic |Nishith Reddy |Nicholas Dulvy |Yuxing Yao
Editor’s summaryDesigning structures capable of multiple deformations in response to a single stimulus requires some combination of hybrid material constructs, complex and precise geometric architectures, and multiple stimuli. Although liquid crystal elastomers (LCEs) can undergo large shape changes when driven through their isotropic-nematic transition, the change is typically unidirectional. Yao et al.
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Dec 5, 2024 | 
science.org | Milos S. Simic |Nishith Reddy |Nicholas Dulvy |H. Zargartalebi
Editor’s summaryReagentless biosensing, which is typically based on affinity receptors such as antibodies or aptamers, has the intrinsic challenge of slow dissociation of protein analytes, especially for the high-affinity interactions needed to achieve high sensitivity. This challenge has impeded the ability to do continuous sensing. Zargartalebi et al.
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Dec 5, 2024 | 
science.org | Milos S. Simic |Nishith Reddy |Nicholas Dulvy |Alexander Carver
AbstractMaintaining genome integrity is an essential and challenging process. RAD51 recombinase, the central player of several crucial processes in repairing DNA and protecting genome integrity, forms filaments on DNA, which are tightly regulated. One of these RAD51 regulators is FIGNL1, that prevents persistent RAD51 foci without or after DNA damage and genotoxic chromatin association in cells.
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Dec 5, 2024 | 
science.org | Milos S. Simic |Nishith Reddy |Nicholas Dulvy |Payal B. Watchmaker
Editor’s summaryCells modified outside of the body and then reintroduced provide an advantage over most small-molecule therapeutics in that cells can be designed to recognize target molecules in specific tissues and then act locally. Two studies now demonstrate advances in cell engineering for treating human disease (see the Perspective by Davila and Brentjens). Reddy et al.
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Dec 5, 2024 | 
science.org | Milos S. Simic |Nishith Reddy |Nicholas Dulvy |Mark Urban
Editor’s summaryBecause it is clear that human activities are altering the global climate, researchers have been studying potential effects and predicting declines and extinctions. Understanding the consequences globally requires the synthesis of many studies.
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Dec 5, 2024 | 
science.org | Milos S. Simic |Nishith Reddy |Nicholas Dulvy |Octavio Aburto-Oropeza
Skip to main content Main content starts here Octavio Aburto-Oropeza , Catalina López-Sagástegui, [...] , Alejandro Robles, and Exequiel Ezcurra+1 authors fewerAuthors Info & AffiliationsScience5 Dec 2024Vol 386, Issue 6726pp. 1102-1103Get full access to this articleView all available purchase options and get full access to this article. References and Notes1R. Pèrez Ortega, Science 384, 500 (2024). 2C.
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Dec 5, 2024 | 
science.org | Milos S. Simic |Nishith Reddy |Nicholas Dulvy |Corinne N. Simonti
Pigmentation A microRNA controls wing pigmentationCorinne SimontiA microRNA is responsible for a common color variation pattern in butterflies. Wing coloration patterns have been widely studied across butterflies and moths, with the gene cortex often being implicated as a recurrent target of selection. However, molecular studies disrupting cortex have had inconsistent results. Tian et al.
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Dec 5, 2024 | 
science.org | Milos S. Simic |Nishith Reddy |Nicholas Dulvy |Heather Wilson
Today, more than at any time since World War II, the United States is being challenged scientifically on the global stage. Unfortunately, the nation is not meeting the moment. With a new administration in the wings, the country must begin to monitor scientific advancements to avoid technological surprise and develop strategies to close the critical technologies gap.
