Alexander Carver

Jan 13, 2025 | science.org | Harrison J. Ostridge |Arindam Ghosh |Anqi Wei |Alexander Carver

AbstractMaintaining genome integrity is an essential and challenging process. RAD51 recombinase, the central player of several crucial processes in repairing DNA and protecting genome integrity, forms filaments on DNA, which are tightly regulated. One of these RAD51 regulators is FIGNL1, that prevents persistent RAD51 foci without or after DNA damage and genotoxic chromatin association in cells.

Dec 5, 2024 | science.org | Milos S. Simic |Nishith Reddy |Nicholas Dulvy |Alexander Carver

AbstractMaintaining genome integrity is an essential and challenging process. RAD51 recombinase, the central player of several crucial processes in repairing DNA and protecting genome integrity, forms filaments on DNA, which are tightly regulated. One of these RAD51 regulators is FIGNL1, that prevents persistent RAD51 foci without or after DNA damage and genotoxic chromatin association in cells.