Mineto Ota

Sep 17, 2023 | biorxiv.org | Joshua Weinstock |Maya M. Arce |Jacob W. Freimer |Mineto Ota

AbstractThe effects of genetic variation on complex traits act mainly through changes in gene regulation. Although many genetic variants have been linked to target genes in cis, the trans-regulatory cascade mediating their effects remains largely uncharacterized. Mapping trans-regulators based on natural genetic variation, including eQTL mapping, has been challenging due to small effects. Experimental perturbation approaches offer a complementary and powerful approach to mapping trans-regulators.