Mingu Kang

Mar 27, 2024 | jbc.org | Byrne D.P |Mingu Kang |Larner College |Amanda J. Senatore

ABSTRACTFocal adhesions (FAs) form the junction between extracellular matrix (ECM)-bound integrins and the actin cytoskeleton and also transmit signals that regulate cell adhesion, cytoskeletal dynamics, and cell migration. While many of these signals are rooted in reversible tyrosine phosphorylation, phosphorylation of FA proteins on Ser/Thr residues is far more abundant yet its mechanisms and consequences are far less understood.