Mir Khalid

Oct 30, 2023 | biorxiv.org | Lauren Hall |Mir Khalid |Melanie Ott

AbstractColloidal aggregation is one of the largest contributors to false-positives in early drug discovery and chemical biology. Much work has focused on its impact on pure-protein screens; here we consider aggregations role in cell-based infectivity assays in Covid-19 drug repurposing. We began by investigating the potential aggregation of 41 drug candidates reported as SARs-CoV-2 entry inhibitors.