Miranda Pitt

Feb 24, 2023 | nature.com | Mark Davies |Stephan Brouwer |Magnus G. Jespersen |Amanda J. Cork |Andrew Hayes |Miranda Pitt | +7 more

AbstractA new variant of Streptococcus pyogenes serotype M1 (designated ‘M1UK’) has been reported in the United Kingdom, linked with seasonal scarlet fever surges, marked increase in invasive infections, and exhibiting enhanced expression of the superantigen SpeA. The progenitor S. pyogenes ‘M1global’ and M1UK clones can be differentiated by 27 SNPs and 4 indels, yet the mechanism for speA upregulation is unknown.