Miriam Ferrer

Jun 1, 2024 | nature.com | Qingtao Sun |Miriam Ferrer |Melody Wu |Youngkyu Park |Jessica Tollkuhn |Tobias Janowitz

AbstractInterleukin-6 (IL-6) has been long considered a key player in cancer cachexia. It is believed that sustained elevation of IL-6 production during cancer progression causes brain dysfunctions, which ultimately result in cachexia. However, how peripheral IL-6 influences the brain remains poorly understood. Here we show that neurons in the area postrema (AP), a circumventricular structure in the hindbrain, is a critical mediator of IL-6 function in cancer cachexia in male mice.

May 18, 2023 | biorxiv.org | Ying Liu |Ezequiel Dantas |Miriam Ferrer |Yifang Liu

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