Miriam Moffatt

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Articles

Microbiome diversity, intra-mucosal bacteria and immune integration within normal and asthmatic airway mucosa

Aug 27, 2024 | biorxiv.org | Miriam Moffatt |Michael Cox |Claire McBrien |Tamiko Nishimura

AbstractAsthma is characterized by reduced bronchial bacterial diversity and airway mucosal disruption. We examined spatial distributions of microbial sequences and host mucosal transcripts in bronchial biopsies from healthy controls and adult asthmatics. Bacteria were discovered by 16S ribosomal RNA staining in the lamina propria of all biopsies, with counts positively associated to lumenal bacterial diversity.

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